Life Extension

TMG 500 mg (Trimethylglycine) by Life Extension – 60 Liquid Vegetarian Capsules

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What Is TMG 500 mg?

Life Extension's TMG 500 mg delivers trimethylglycine (TMG) — also known as betaine — a naturally occurring compound that plays a central role in methylation, one of the body’s most critical biochemical processes. TMG is a primary methyl donor that supports healthy homocysteine metabolism, cardiovascular health, liver function, and cellular methylation pathways — all in convenient liquid vegetarian capsules for enhanced absorption.

Key Benefits

Promotes healthy homocysteine levels – TMG directly donates methyl groups to convert homocysteine into methionine, helping keep this cardiovascular risk marker in a healthy range
Cardiovascular protection – Elevated homocysteine is a well-established risk factor for heart and arterial health; TMG supports its safe metabolism
Methylation support – As a potent methyl donor, TMG supports hundreds of methylation-dependent reactions including DNA synthesis, neurotransmitter production, and detoxification
Liver health – TMG supports healthy liver fat metabolism and is used clinically to support liver function in fatty liver conditions
Athletic performance – Emerging research links TMG supplementation to improved power output, endurance, and body composition
Cognitive & mood support – Healthy methylation is essential for the production of SAMe, dopamine, and serotonin — key mood and brain health regulators

What Makes It Different?

TMG works synergistically with folate, B6, and B12 to support complete homocysteine metabolism — making it a smart addition to any cardiovascular or methylation support stack. Life Extension uses a liquid vegetarian capsule format for superior bioavailability compared to standard compressed tablets, ensuring TMG is absorbed quickly and efficiently. At 500 mg per capsule, dosing is flexible and easy to adjust.

Who Should Take This?

Adults with elevated homocysteine levels or cardiovascular health concerns
Those with MTHFR gene variants or impaired methylation capacity
Individuals looking to complement B-vitamin supplementation with a methyl donor
Athletes seeking performance and body composition support
Anyone focused on liver health, detoxification, or comprehensive longevity support

Product Highlights

60 Liquid Vegetarian Capsules per bottle (30–60-day supply)
500 mg trimethylglycine (TMG/betaine) per capsule
Liquid capsule format for enhanced absorption vs. tablets
Promotes healthy homocysteine levels
Non-GMO Verified | Gluten-Free
Manufactured by Life Extension – evidence-based supplementation since 1980

Directions for Use

Take one (1) to two (2) capsules daily with food, or as recommended by a healthcare practitioner.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Supplement Facts

Supplement Facts
Serving Size: 1 Liquid Vegetarian Capsule
Servings Per Container: 60

Trimethylglycine (TMG, anhydrous betaine) – 500 mg

Other Ingredients: Extra virgin olive oil, vegetable glycerin, purified water, vegetable cellulose (capsule), beeswax, sunflower lecithin.

Contains no: gluten, GMOs, artificial colors, artificial flavors, or preservatives.

Directions

Take one (1) to two (2) capsules daily with food, or as recommended by a healthcare practitioner.

Warnings

Keep out of reach of children. Do not use if seal is broken. Store in a cool, dry place away from moisture and heat. Consult a healthcare provider before use if pregnant, nursing, taking medications, or have kidney disease. TMG may increase LDL cholesterol in some individuals – consult your physician if monitoring lipid levels.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.