Thorne Vitamin C 500mg with Flavonoids – Enhanced Antioxidant, Immune & Collagen Support, 90 Capsules

What Is Thorne Vitamin C 500mg with Flavonoids?

Thorne Vitamin C 500mg with Flavonoids delivers 500 mg of Vitamin C (Ascorbic Acid) per capsule enhanced with a synergistic blend of citrus bioflavonoids — naturally occurring plant polyphenols found alongside Vitamin C in whole citrus fruits that dramatically potentiate Vitamin C’s biological activity and tissue retention. This is a meaningful distinction from plain ascorbic acid supplements: in nature, Vitamin C never exists in isolation — it is always accompanied by flavonoids that modulate its absorption, extend its half-life in tissues, and multiply its antioxidant and vascular protective effects. Thorne’s formulation replicates this whole-food synergy in a concentrated, standardized capsule format. NSF Certified for Sport®.

Why Flavonoids with Vitamin C?

Citrus flavonoids (including hesperidin, rutin, naringenin, and quercetin-related compounds) work alongside Vitamin C through multiple mechanisms:

• Enhanced Vitamin C Absorption & Tissue Retention — Flavonoids inhibit the enzymatic breakdown (oxidation) of Vitamin C in the gut and bloodstream, increasing the effective amount of Vitamin C that reaches tissues. Clinical studies show flavonoid co-administration improves Vitamin C bioavailability and extends its plasma half-life compared to ascorbic acid alone
• Synergistic Antioxidant Activity — Flavonoids are potent antioxidants in their own right, neutralizing reactive oxygen species (ROS) through direct radical scavenging and by regenerating oxidized Vitamin C (dehydroascorbic acid) back to its active ascorbate form — effectively recycling Vitamin C and amplifying its antioxidant capacity
• Vascular & Capillary Protection — Flavonoids, particularly hesperidin and rutin, strengthen capillary walls by stabilizing collagen in blood vessel walls and reducing capillary permeability and fragility — complementing Vitamin C’s own collagen synthesis role in vascular integrity
• Anti-inflammatory Activity — Flavonoids inhibit pro-inflammatory enzymes (COX, LOX, phospholipase A2) and downregulate NF-κB inflammatory signaling, providing anti-inflammatory benefits beyond Vitamin C’s antioxidant activity alone

What Does Vitamin C 500mg with Flavonoids Do?

• Immune System Defense — Vitamin C is the most extensively researched micronutrient for immune support. It supports both the innate (neutrophil, macrophage, NK cell function) and adaptive (lymphocyte proliferation, antibody production) immune systems. Vitamin C accumulates in immune cells at concentrations 50–100x higher than plasma, where it protects immune cells from oxidative self-damage during phagocytosis and pathogen killing. Clinical meta-analyses confirm Vitamin C reduces the duration of upper respiratory infections and supports faster recovery
• Collagen Synthesis & Connective Tissue Integrity — Vitamin C is the essential cofactor for prolyl hydroxylase and lysyl hydroxylase — the enzymes required for collagen cross-linking and stabilization. Without adequate Vitamin C, collagen cannot form the triple helix structure that gives it tensile strength. This is critical for skin elasticity and wound healing, tendon and ligament integrity, arterial wall strength, gum and dental health, and bone matrix formation (collagen makes up 30% of bone by weight)
• Antioxidant Protection — Vitamin C is the body’s primary water-soluble antioxidant, protecting aqueous cellular compartments (cytoplasm, blood plasma) from oxidative damage. It also regenerates Vitamin E (the primary fat-soluble antioxidant) from its oxidized form, creating a synergistic antioxidant network across both water- and fat-soluble compartments
• Iron Absorption Enhancement — Vitamin C reduces ferric iron (Fe³⁺) to the more absorbable ferrous form (Fe²⁺) in the gut, increasing non-heme iron absorption by 2–6 fold. This is particularly important for vegans, vegetarians, and anyone with iron deficiency taking plant-based iron sources
• Neurotransmitter & Hormone Synthesis — Vitamin C is a required cofactor for dopamine beta-hydroxylase (converting dopamine to norepinephrine), for the synthesis of carnitine (essential for fatty acid transport into mitochondria), and for amidation of neuropeptide hormones. These roles make Vitamin C critical for energy metabolism, mood, and cognitive function beyond its antioxidant role
• Skin Health & Anti-Aging — Vitamin C is the most clinically validated topical and oral nutrient for skin collagen synthesis, UV-induced oxidative damage protection, melanin synthesis inhibition (reducing hyperpigmentation), and overall skin elasticity. The flavonoids in this formula further contribute through their own UV-protective and anti-inflammatory skin benefits
• Cardiovascular Protection — Combined Vitamin C and flavonoids support endothelial function, reduce LDL oxidation (a primary driver of atherosclerosis), improve arterial flexibility, and support healthy blood pressure through vasodilation and reduced vascular inflammation

Why 500mg? Optimal Dosing for Daily Maintenance

Vitamin C is water-soluble and not stored in large amounts — plasma saturation occurs at approximately 200 mg/day, but tissue saturation — particularly in adrenal glands, white blood cells, and the brain — requires higher ongoing intake. The 500 mg per capsule format allows flexible maintenance dosing (1 capsule/day for general health) or therapeutic dosing (2–3 capsules/day for immune support, stress, or recovery) without the GI discomfort that higher single doses (1,000+ mg) can cause. Divided dosing at 500 mg increments maximizes absorption as intestinal Vitamin C transporters become saturated at single doses above 200–400 mg.

Who Should Take This?

• Anyone seeking daily immune system maintenance and antioxidant protection
• Individuals with high oxidative stress from exercise, smoking, pollution, or chronic illness
• Those supporting collagen synthesis for skin health, wound healing, joint integrity, or dental health
• Vegans and vegetarians enhancing non-heme iron absorption from plant-based diets
• Individuals under high physical or psychological stress with elevated Vitamin C utilization
• Athletes supporting recovery, collagen repair, and immune resilience post-training
• Competitive athletes requiring NSF Certified for Sport® verified supplements

How to Use

Take 1–2 capsules daily with a meal, or as directed by your healthcare practitioner. For optimal absorption, divide doses throughout the day rather than taking all at once (intestinal Vitamin C transporters saturate at single doses above ~400 mg). Take with food to reduce the possibility of GI discomfort from ascorbic acid. For therapeutic immune or collagen support, 2–3 capsules daily in divided doses may be appropriate under healthcare practitioner guidance.

Product Highlights

• 500mg Vitamin C (Ascorbic Acid) per capsule with citrus bioflavonoids
• Flavonoids enhance absorption, extend tissue half-life & amplify antioxidant activity
• Supports Immune Defense, Collagen Synthesis, Antioxidant Protection & Iron Absorption
• Hesperidin, Rutin & related flavonoids for vascular and capillary protection
• 90 Capsules — 90-day supply at 1 capsule/day | NSF Certified for Sport®
• No unnecessary excipients | From Thorne — trusted by healthcare practitioners worldwide