Thorne Magnesium CitraMate™ – Magnesium Citrate-Malate | Supports Energy, Muscle, Nerve & Cardiovascular Health, 90 Capsules

What Is Thorne Magnesium CitraMate™?

Thorne Magnesium CitraMate™ delivers magnesium as a unique citrate-malate complex — combining magnesium with both citric acid and malic acid, two key organic acids that are direct intermediates in the Krebs cycle (citric acid cycle), the mitochondrial pathway responsible for generating the majority of the body’s cellular energy (ATP). This dual-acid complex offers a distinct advantage over single-chelate magnesium forms: not only does it provide highly bioavailable magnesium, but the citrate and malate anions themselves contribute directly to mitochondrial energy metabolism, making Magnesium CitraMate™ the preferred magnesium form for individuals whose primary goals are energy production, fatigue reduction, and metabolic support — in addition to the full spectrum of magnesium’s systemic benefits. NSF Certified for Sport®.

What Makes Citrate-Malate Unique?

• Citrate (Citric Acid) — A central intermediate in the Krebs cycle; enters the mitochondria directly to support ATP synthesis, helps buffer lactic acid accumulation during exercise, and supports kidney stone prevention by increasing urinary citrate levels (a potent inhibitor of calcium oxalate crystal formation)
• Malate (Malic Acid) — Another direct Krebs cycle intermediate; plays a critical role in the malate-aspartate shuttle, which transfers reducing equivalents into the mitochondria for ATP production. Malic acid supplementation has been specifically studied for fibromyalgia, chronic fatigue syndrome, and exercise-induced muscle pain, showing improvements in energy, pain reduction, and exercise tolerance
• Combined Effect — The citrate-malate complex simultaneously delivers bioavailable magnesium and two mitochondrial energy substrates in a single capsule, making this form uniquely suited for energy-focused applications compared to glycinate (sleep/relaxation-focused) or oxide (laxative-effect, low bioavailability)

What Does Magnesium CitraMate™ Do?

• Cellular Energy Production & Fatigue Reduction — Magnesium is required for every ATP-dependent enzymatic reaction in the body (ATP must be bound to magnesium to be biologically active), while citrate and malate directly feed into the Krebs cycle. This triple-action energy support makes CitraMate™ particularly effective for individuals with chronic fatigue, fibromyalgia, post-exercise fatigue, and energy metabolism impairment
• Muscle Function, Recovery & Cramp Prevention — Magnesium is the physiological antagonist of calcium in muscle cells — calcium triggers contraction, magnesium enables relaxation. Adequate magnesium prevents muscle cramps, spasms, and delayed-onset muscle soreness (DOMS). Malic acid’s role in lactic acid buffering further supports faster post-exercise recovery and reduced muscle pain
• Nervous System Regulation & Stress Resilience — Magnesium regulates NMDA glutamate receptors (preventing excitotoxicity), supports GABA-ergic calming signaling, and modulates the HPA (hypothalamic-pituitary-adrenal) axis stress response. Deficiency is strongly associated with anxiety, hyperirritability, and poor stress tolerance
• Cardiovascular Health — Magnesium supports healthy blood pressure through smooth muscle relaxation and vasodilation, regulates cardiac rhythm by modulating calcium flux in cardiac cells, and supports healthy cholesterol and blood glucose metabolism. Epidemiological data consistently links higher magnesium intake with lower cardiovascular disease risk
• Kidney Stone Prevention — Magnesium and citrate work synergistically to reduce urinary calcium oxalate supersaturation — the primary driver of the most common form of kidney stones. Citrate inhibits calcium oxalate crystal growth and aggregation in the urinary tract, and magnesium reduces intestinal oxalate absorption
• Blood Sugar & Insulin Sensitivity — Magnesium is a required cofactor for insulin receptor tyrosine kinase activity. Deficiency impairs insulin signaling, and supplementation supports improved insulin sensitivity and healthy postprandial blood glucose regulation
• Bone Health — Over 60% of the body’s magnesium is stored in bone as a structural component of the bone mineral matrix. Adequate magnesium is essential for hydroxyapatite crystal formation, bone mineral density, and the proper function of osteoblasts (bone-building cells)

Magnesium CitraMate™ vs. Other Magnesium Forms

• vs. Magnesium Glycinate — Glycinate is the preferred form for sleep and relaxation (glycine has direct calming receptor activity). CitraMate™ is the preferred form for energy production, fatigue, and metabolic support due to the Krebs cycle contribution of citrate and malate
• vs. Magnesium Citrate — Standard citrate provides citric acid but not malic acid. CitraMate™’s addition of malate adds a second Krebs cycle intermediate, broadening mitochondrial energy support and adding malic acid’s specific benefits for fibromyalgia and muscle pain
• vs. Magnesium Oxide — Oxide has very low bioavailability (~4%) and primarily acts as a laxative. CitraMate™ is substantially more bioavailable and does not cause diarrhea at standard doses
• vs. Magnesium Malate — Pure malate provides malic acid but not citrate. CitraMate™’s inclusion of both citrate and malate provides broader Krebs cycle coverage and the additional kidney stone prevention benefit of citrate

Who Should Take This?

• Individuals with chronic fatigue, low energy, or fibromyalgia seeking mitochondrial energy support
• Athletes seeking faster muscle recovery, cramp prevention, and reduced exercise-induced fatigue
• Those supporting cardiovascular health through blood pressure and cardiac rhythm regulation
• Individuals with a history of kidney stones (calcium oxalate type) seeking magnesium + citrate prevention support
• People with metabolic concerns including blood sugar regulation and insulin sensitivity
• Anyone with suboptimal magnesium intake who primarily needs energy and metabolic support (vs. sleep support)
• Competitive athletes requiring NSF Certified for Sport® verified supplements

How to Use

Take 1–3 capsules daily with a meal, or as directed by your healthcare practitioner. For energy and metabolic support, morning or midday dosing with food is recommended. For muscle recovery, take after exercise. Start with 1 capsule daily and increase gradually to assess individual tolerance. For sleep support, consider Thorne Magnesium Glycinate instead, which pairs glycine’s calming effects with magnesium’s relaxation benefits.

Product Highlights

• Magnesium Citrate-Malate — dual Krebs cycle intermediate for enhanced energy support
• Supports Cellular Energy (ATP), Muscle Recovery & Fatigue Reduction
• Malic Acid — specifically studied for fibromyalgia and chronic fatigue
• Citrate — supports kidney stone prevention and lactic acid buffering
• Supports Cardiovascular Health, Blood Sugar & Bone Density
• 90 Capsules | NSF Certified for Sport® | No unnecessary excipients
• From Thorne — trusted by healthcare practitioners worldwide