NOW UC-II® Joint Health – Undenatured Type II Collagen, Promotes Healthy Joint Comfort & Function, 120 Capsules

What Is NOW UC-II®?

NOW UC-II® features patented Undenatured Type II Collagen — a clinically researched joint health ingredient derived from chicken sternum cartilage that works through a completely different and more advanced mechanism than standard collagen supplements. While conventional hydrolyzed collagen peptides provide structural amino acid building blocks for joint tissue, UC-II® works through oral tolerization — a sophisticated immune-mediated process that actively retrains the immune system to stop attacking joint cartilage, reducing joint inflammation at its immunological root. Just 40 mg per day — a fraction of the multi-gram doses required by standard collagen products — is the clinically validated dose shown in multiple randomized controlled trials to support joint comfort, flexibility, and function.

The Science: How Oral Tolerization Works

In many joint conditions, the immune system mistakenly identifies native Type II collagen in cartilage as a foreign threat, triggering an inflammatory attack on joint tissue. UC-II® works by introducing small amounts of undenatured (native, intact) Type II collagen to immune cells in the gut-associated lymphoid tissue (GALT), particularly Peyer’s patches in the small intestine. This re-educates regulatory T cells (Tregs) to recognize Type II collagen as “self” rather than “foreign,” suppressing the autoimmune-like inflammatory cascade that degrades cartilage. This mechanism — oral tolerization — is fundamentally distinct from and clinically superior to simply ingesting collagen peptides.

Clinical Evidence

• UC-II® has been studied in multiple double-blind, placebo-controlled clinical trials
• Shown to outperform glucosamine + chondroitin combination in joint comfort and flexibility endpoints in head-to-head trials
• Effective in both healthy active individuals and those with joint discomfort
• Results typically observed within 60–90 days of consistent daily use

What Does UC-II® Support?

• Healthy joint comfort — Reduces joint discomfort through immune tolerization of cartilage collagen
• Joint function & mobility — Supports range of motion, flexibility, and ease of movement
• Cartilage integrity — Helps protect existing cartilage from immune-mediated degradation
• Exercise-induced joint stress — Supports recovery from physical activity and joint loading
• Long-term joint health — Proactive support for joint longevity in active individuals and older adults

Who Should Take This?

• Adults with occasional or chronic joint discomfort, stiffness, or reduced mobility
• Athletes and active individuals seeking joint protection and recovery support
• Those who have not achieved sufficient results from glucosamine and chondroitin
• Older adults proactively supporting cartilage and joint health
• Anyone looking for a low-dose, science-backed joint health solution

How to Use

Take 1 capsule daily on an empty stomach (at least 30 minutes before a meal), or as directed by your healthcare practitioner. The oral tolerization mechanism of UC-II® requires the undenatured collagen to interact with gut immune tissue before food is present — taking on an empty stomach is essential for maximum efficacy. Allow 60–90 days of consistent daily use for full benefits.

Product Highlights

• 40 mg UC-II® Undenatured Type II Collagen per capsule — patented, clinically validated
• Works via oral tolerization — immunological mechanism, not just structural support
• Clinically shown to outperform glucosamine + chondroitin
• Joint Comfort, Flexibility & Cartilage Protection
• 120 Capsules — 120-day supply at 1 capsule/day
• Non-GMO Verified
• No artificial colors, flavors, or preservatives
• Family Owned Since 1968