NOW Ashwagandha 450 mg – Standardized Extract, Ayurvedic Adaptogen, Free Radical Scavenger & Immune System Support, 90 Veg Capsules

What Is NOW Ashwagandha 450 mg?

NOW Ashwagandha 450 mg features a standardized extract of Withania somnifera root — one of the most revered herbs in Ayurvedic medicine, used for over 3,000 years as a Rasayana (rejuvenating tonic) to promote vitality, resilience, and longevity. Modern science has validated what Ayurvedic practitioners have known for millennia: Ashwagandha is a true adaptogen — a botanical that helps the body adapt to physical, mental, and environmental stressors by modulating the HPA (hypothalamic-pituitary-adrenal) axis, the body’s central stress-response system. Standardized to ensure consistent levels of the bioactive withanolides — the steroidal lactones responsible for its adaptogenic, anti-inflammatory, and neuroprotective effects — NOW’s extract delivers reliable, research-aligned potency in every capsule.

How Ashwagandha Works as an Adaptogen

Unlike stimulants that force alertness or sedatives that force calm, adaptogens like ashwagandha work by normalizing physiological responses to stress. Ashwagandha’s primary mechanisms include:

• Cortisol modulation — Clinically shown to reduce serum cortisol levels, the primary stress hormone that drives fatigue, anxiety, weight gain, and immune suppression when chronically elevated
• HPA axis regulation — Balances the hypothalamic-pituitary-adrenal stress response for a more measured, resilient reaction to stressors
• GABA-mimetic activity — Withanolides bind to GABA receptors, promoting calming neurological effects without sedation
• Antioxidant defense — Powerful free radical scavenging activity protecting cells from oxidative stress

What Does Ashwagandha Support?

• Stress & anxiety relief — Multiple RCTs demonstrate significant reductions in perceived stress and anxiety scores with standardized ashwagandha extract
• Immune system support — Modulates immune cell activity (NK cells, macrophages) and supports healthy inflammatory balance
• Free radical scavenging — Rich in withanolides and sitoindosides with potent antioxidant activity
• Energy & vitality — Supports adrenal health and mitochondrial function for sustained, non-jittery energy
• Sleep quality — Triethylene glycol (TEG) in ashwagandha leaf promotes non-REM sleep; root extract supports restful sleep through cortisol reduction
• Thyroid support — May support healthy thyroid hormone levels (T3/T4) in those with subclinical hypothyroid tendencies
• Athletic performance — Supports muscle strength, recovery, and VO2 max in clinical trials
• Cognitive function — Supports memory, reaction time, and mental clarity through neuroprotective withanolide activity

Who Should Take This?

• Individuals under chronic stress seeking natural cortisol and HPA axis support
• Those experiencing stress-related fatigue, burnout, or adrenal exhaustion
• People seeking better sleep quality without pharmaceutical sedatives
• Athletes wanting natural support for performance, strength, and recovery
• Anyone building a longevity, immune, or cognitive support stack

How to Use

Take 1 capsule 2 to 3 times daily with food, or as directed by your healthcare practitioner. For stress and sleep support, taking one dose in the evening with dinner is particularly beneficial. Allow 4–8 weeks of consistent use for full adaptogenic benefits as cortisol regulation normalizes.

Product Highlights

• 450 mg Standardized Ashwagandha Root Extract (Withania somnifera) per capsule
• Standardized for withanolide content — consistent, research-aligned potency
• Ayurvedic Adaptogen — Free Radical Scavenger — Immune Support
• Clinically studied for cortisol reduction and stress relief
• Vegetarian/Vegan capsules
• 90 Veg Capsules — 30 to 45-day supply
• Non-GMO Verified
• No artificial colors, flavors, or preservatives
• Family Owned Since 1968