L-Citrulline and Blood Vessel Function: What a Human Trial Found
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A four-week randomized trial in 25 postmenopausal women with high blood pressure found that L-citrulline improved how well an arm artery widened in response to increased blood flow compared with placebo.
What improved
Flow-mediated dilation increased by 1.4 percentage points in the L-citrulline group and decreased by 0.5 percentage points in the placebo group. This ultrasound measure describes how an artery responds to changes in blood flow.
What the study can tell us
This was a short trial in a specific group. It offers evidence about artery function under the study conditions. It did not establish long-term cardiovascular benefits or that L-citrulline can replace blood pressure treatment.
Read the original clinical trial.