{"product_id":"now-uc-ii-joint-health-undenatured-type-ii-collagen-healthy-joint-comfort-function-120-capsules","title":"NOW UC-II® Joint Health – Undenatured Type II Collagen, Promotes Healthy Joint Comfort \u0026 Function, 120 Capsules","description":"\u003ch2\u003eWhat Is NOW UC-II®?\u003c\/h2\u003e\u003cp\u003eNOW UC-II® features patented \u003cstrong\u003eUndenatured Type II Collagen\u003c\/strong\u003e — a clinically researched joint health ingredient derived from chicken sternum cartilage that works through a completely different and more advanced mechanism than standard collagen supplements. While conventional hydrolyzed collagen peptides provide structural amino acid building blocks for joint tissue, UC-II® works through \u003cstrong\u003eoral tolerization\u003c\/strong\u003e — a sophisticated immune-mediated process that actively \u003cem\u003eretrains\u003c\/em\u003e the immune system to stop attacking joint cartilage, reducing joint inflammation at its immunological root. Just \u003cstrong\u003e40 mg per day\u003c\/strong\u003e — a fraction of the multi-gram doses required by standard collagen products — is the clinically validated dose shown in multiple randomized controlled trials to support joint comfort, flexibility, and function.\u003c\/p\u003e\u003ch2\u003eThe Science: How Oral Tolerization Works\u003c\/h2\u003e\u003cp\u003eIn many joint conditions, the immune system mistakenly identifies native Type II collagen in cartilage as a foreign threat, triggering an inflammatory attack on joint tissue. UC-II® works by introducing small amounts of \u003cstrong\u003eundenatured (native, intact) Type II collagen\u003c\/strong\u003e to immune cells in the gut-associated lymphoid tissue (GALT), particularly Peyer’s patches in the small intestine. This re-educates regulatory T cells (Tregs) to recognize Type II collagen as “self” rather than “foreign,” suppressing the autoimmune-like inflammatory cascade that degrades cartilage. This mechanism — oral tolerization — is fundamentally distinct from and clinically superior to simply ingesting collagen peptides.\u003c\/p\u003e\u003ch2\u003eClinical Evidence\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eUC-II® has been studied in multiple double-blind, placebo-controlled clinical trials\u003c\/li\u003e\n\u003cli\u003eShown to outperform glucosamine + chondroitin combination in joint comfort and flexibility endpoints in head-to-head trials\u003c\/li\u003e\n\u003cli\u003eEffective in both healthy active individuals and those with joint discomfort\u003c\/li\u003e\n\u003cli\u003eResults typically observed within 60–90 days of consistent daily use\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eWhat Does UC-II® Support?\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHealthy joint comfort\u003c\/strong\u003e — Reduces joint discomfort through immune tolerization of cartilage collagen\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eJoint function \u0026amp; mobility\u003c\/strong\u003e — Supports range of motion, flexibility, and ease of movement\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCartilage integrity\u003c\/strong\u003e — Helps protect existing cartilage from immune-mediated degradation\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExercise-induced joint stress\u003c\/strong\u003e — Supports recovery from physical activity and joint loading\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLong-term joint health\u003c\/strong\u003e — Proactive support for joint longevity in active individuals and older adults\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eWho Should Take This?\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eAdults with occasional or chronic joint discomfort, stiffness, or reduced mobility\u003c\/li\u003e\n\u003cli\u003eAthletes and active individuals seeking joint protection and recovery support\u003c\/li\u003e\n\u003cli\u003eThose who have not achieved sufficient results from glucosamine and chondroitin\u003c\/li\u003e\n\u003cli\u003eOlder adults proactively supporting cartilage and joint health\u003c\/li\u003e\n\u003cli\u003eAnyone looking for a low-dose, science-backed joint health solution\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eHow to Use\u003c\/h2\u003e\u003cp\u003eTake 1 capsule daily on an empty stomach (at least 30 minutes before a meal), or as directed by your healthcare practitioner. The oral tolerization mechanism of UC-II® requires the undenatured collagen to interact with gut immune tissue before food is present — taking on an empty stomach is essential for maximum efficacy. Allow 60–90 days of consistent daily use for full benefits.\u003c\/p\u003e\u003ch2\u003eProduct Highlights\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e40 mg UC-II® Undenatured Type II Collagen per capsule — patented, clinically validated\u003c\/li\u003e\n\u003cli\u003eWorks via oral tolerization — immunological mechanism, not just structural support\u003c\/li\u003e\n\u003cli\u003eClinically shown to outperform glucosamine + chondroitin\u003c\/li\u003e\n\u003cli\u003eJoint Comfort, Flexibility \u0026amp; Cartilage Protection\u003c\/li\u003e\n\u003cli\u003e120 Capsules — 120-day supply at 1 capsule\/day\u003c\/li\u003e\n\u003cli\u003eNon-GMO Verified\u003c\/li\u003e\n\u003cli\u003eNo artificial colors, flavors, or preservatives\u003c\/li\u003e\n\u003cli\u003eFamily Owned Since 1968\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"NOW Foods","offers":[{"title":"60","offer_id":52787632210202,"sku":"NOW-UCII-JOINT-120CAP-1","price":26.0,"currency_code":"USD","in_stock":true},{"title":"120","offer_id":52787632242970,"sku":"NOW-UCII-JOINT-120CAP-2","price":46.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/7007\/9258\/files\/UC-II.jpg?v=1788425986","url":"https:\/\/bpbalance.com\/products\/now-uc-ii-joint-health-undenatured-type-ii-collagen-healthy-joint-comfort-function-120-capsules","provider":"BPBalance","version":"1.0","type":"link"}